Oleuropein: A natural antioxidant molecule in the treatment of metabolic syndrome


  • 1Faculty of Pharmacy, Tishk International University, Erbil, Iraq.
  • 2Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.
  • 3Department of Pharmacognosy, School of Pharmaceutical Education and Research (Formerly Faculty of Pharmacy), Jamia Hamdard, New Delhi, India.
  • 4Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Kingdom of Saudi Arabia.
  1. PMID: 31746508
  2. DOI: 10.1002/ptr.6511


Olive (Olea europaea Linn., Fam. Oleaceae) is commonly known as Zaytoon in Mediterranean region. Its fruits and oil are essential components of Mediterranean diets. Olive tree is a prevalent plant species and one of the important cultivated crops of Mediterranean region. Oleuropein is a phenolic constituents of olive, which, along with its related compounds, has been indicated to be majorly responsible for its beneficial effects. Oleuropein is a secoiridoid type of phenolic compound and consists of three structural subunits: hydroxytyrosol, elenolic acid, and a glucose molecule. It is also reported to be the chemotaxonomic marker of olive. The oleuropein is reported to possess a number of biological activities including action against dyslipidemia, antiobesity, antidiabetic, antioxidant, antiatherogenic, antihypertensive, antiinflammatory, and hepatoprotective actions. The scientific evidence supports the role of oleuropein as a potential agent against metabolic syndrome. The present review discusses chemistry of oleuropein along with potential role of oleuropein with reference to pathophysiology of metabolic syndrome.

Keywords: Olea europaea L; cardiovascular disease; chemistry; diabetes; metabolic syndrome; obesity; oleuropein.


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